Effect of Alcornea cordifolia Aqueous and Methanolic Leaf Extracts against Antituberculosis Drugs Induced Liver Damage in Rats

The hepatoprotective properties of Alchornea cordifolia, a medicinal plant was studied in hepatotoxicity induced animal model with high dose paracetamol or carbon tetrachloride. Knowing that antituberculosis drugs also represent risk factor for hepatotoxicity, could A. cordifolia play key role to limit their hepatotoxicity? objective this study assess the histological changes rat livers and evolution after administration an aqueous methanolic leaf extracts therefore estimate polyphenol flavonoid contents. Rats were divided into three (3) groups: group 1 treated isoniazid; 2 received combination isoniazid rifampicin 3 given isoniazid, pyraziamide. For each rats, hepatotoxicant either administered alone two hours before (200, 400, 800 mg/kg) day 10 days. Animals sacrificed on 11 removed histolopathological analysis. In addition, total contents estimated both extracts. Antituberculosis drug combinations caused peliosis lesions, steatosis hepatocyte necrosis. liver histology rats showed ability annihilate alleviate hepatocellular damage by such drugs. extract, richer polyphenols (0.55 ± 0.02 mg EGA) than extract (0.35 0.01 demonstrated greater effect. Thus, according analysis, attenuate rats.